LCRMP-1 induces tumor angiogenesis by transcriptionally upregulating SERPINE1 in lung adenocarcinoma.

ABSTRACT: Angiogenesis is a crucial process in cancer progression, particularly in malignant tumors, as it facilitates tumor growth and metastasis by generating new blood vessels that supply vital nutrients and oxygen. However, the regulatory mechanism governing the development of these tumor neo-vessels by endothelial cells is still not fully understood. This study investigates the role of long-form collapsin response mediator protein-1 (LCRMP-1) in angiogenesis within non-small cell lung cancer (NSCLC). Through in vitro tube formation, in vivo plaque angiogenesis assays, and immunohistochemical staining, we identify SERPINE1 as a crucial factor regulated by LCRMP-1. Mechanistically, LCRMP-1 functions as a co-transcriptional factor, enhancing the expression of SERPINE1 through its interactions with

SUBMITTER: Hsu YL 

PROVIDER: S-EPMC12647825 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature