Crossover interference mediates multiscale patterning along meiotic chromosomes.

ABSTRACT: Meiotic crossover interference is a one-dimensional spatial patterning process that produces evenly-spaced crossovers. Quantitative analysis of diagnostic molecules along budding yeast chromosomes reveals that this process sets up two interdigitated patterns, of shorter and longer periodicity, by "two-tiered" patterning. Both tiers comprise clustered assemblies of three types of molecules ("triads") representing the three major components of meiotic chromosomes (crossover recombination, axes, and the synaptonemal complex). One tier of triads occurs at sites of majority ("canonical") crossovers. Second tier triads are more widely spaced but also exhibit interference, dependent on the same functions as canonical crossover interference. Diverse lines of evidence suggest that second tier triad

SUBMITTER: White MA 

PROVIDER: S-EPMC12647850 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature