Endothelial glycocalyx shedding and oxidative stress in neuronal damage after return of spontaneous circulation in cardiac arrest.

ABSTRACT: Endothelial glycocalyx (eGC) covers the luminal surface of all vessels. Recent evidence has highlighted its pivotal role in maintaining the integrity of the blood-brain barrier (BBB). Return of spontaneous circulation (ROSC) after cardiac arrest (CA) is a main example of global ischemia-reperfusion (I/R) injury. I/R injury can induce eGC shedding and redox imbalance. This study aims to evaluate the interplay between eGC shedding and oxidative stress (OS) in determing neuronal injury and predicting neurological outcomes following CA. Blood and urine samples were obtained from patients who achieved ROSC after CA. Biomarkers of eGC shedding (syndecan-1 [SDC-1], CD44s, hyaluronan [HYAL], and sulfated glycosaminoglycans [GAGs], of endothelial injury (thrombomodulin [TBML]), of OS (malondialdehy

SUBMITTER: de Oliveira Couto H 

PROVIDER: S-EPMC12647864 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature