Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice.

ABSTRACT: Senescence-associated frailty and sarcopenia are global challenges. We here investigated neuronal activity and skeletal muscle biology in senescence-accelerated mouse prone 8 (SAMP8) mice with scalp acupuncture stimulation (SAPS). Excise activity was assessed using rotarod test in the three groups: SAMP8 mice receiving SAPS (SP8-Ap), SAMP8 controls (SP8-C), and senescence-accelerated mouse resistant 1 controls (SR1). SP8-Ap exhibited significantly improved exercise activity compared to SP8-C. SAPS increased brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the frontal cortex of SP8-Ap. Monocyte/macrophage infiltration was significantly reduced in the gastrocnemius of SP8-Ap mice, which was associated with reduced expression of various glycogen synthase kinase

SUBMITTER: Nagaoka N 

PROVIDER: S-EPMC12647874 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature