Topological turning points across the human lifespan.

ABSTRACT: Structural topology develops non-linearly across the lifespan and is strongly related to cognitive trajectories. We gathered diffusion imaging from datasets with a collective age range of zero to 90 years old (N = 4,216). We analyzed how 12 graph theory metrics of organization change with age and projected these data into manifold spaces using Uniform Manifold Projection and Approximation. With these manifolds, we identified four major topological turning points across the lifespan - around nine, 32, 66, and 83 years old. These ages defined five major epochs of topological development, each with distinctive age-related changes in topology. These lifespan epochs each have a distinct direction of topological development and specific changes in the organizational properties driving the age-to

SUBMITTER: Mousley A 

PROVIDER: S-EPMC12647875 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature