Stress-induced brain extracellular vesicles ameliorate anxiety behavior.

ABSTRACT: Extracellular vesicles (EVs), nanovesicles secreted by all types of cells, serve as a communication network, carrying information through the bloodstream to distant cells [1, 2]. Notably, brain cells secrete EVs that play a crucial role in regulating neurological functions [3-5]. Meanwhile, the brain detects acute stress and activates mechanisms to enhance stress resistance and maintain homeostasis [6, 7]. However, the specific contribution of brain-derived extracellular vesicles (BDEVs) in modulating the stress response remains elusive. Here we found that administration of the acute stress-induced BDEVs to mice reduced anxiety-related behaviors, and this reduction was also induced by the administration of only three microRNAs (miRNAs) (miR-199a-3p, miR-99b-3p and miR-140-5p) included in t

SUBMITTER: Mizohata Y 

PROVIDER: S-EPMC12647894 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature