Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis.

ABSTRACT:

Background

The aim was to investigate the potential therapeutic targets for ischemic stroke (IS) and vascular dementia (VD).

Methods

We assessed the causal effects of 2943 plasma proteins on IS and VD using a two-sample Mendelian randomization (MR) framework. Results were validated via summary data-based MR (SMR) analysis. A two-step mediation MR analysis was conducted to elucidate potential causal mechanisms by which plasma proteins influence IS and VD through risk factors. We performed a phenome-wide association study (PheWAS) MR analysis to explore side effects and additional indications for IS and VD-associated plasma proteins. We established middle cerebral artery occlusion and reperfusion (MCAO/R) and VD rat models to verify potential therapeutic targets for IS and VD.

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12647924 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature