Antibiotic Susceptibility of <i>Nocardia</i> Clinical Isolates Collected from Chinese Patients - China, 2014-2024.

ABSTRACT:

Introduction

Nocardia species are found worldwide in soil rich in organic matter and can cause nocardiosis in humans. Trimethoprim-sulfamethoxazole has long been the first-line treatment for Nocardia infections; however, resistance to this therapy has recently been reported.

Methods

Sixty-three clinical Nocardia isolates collected in China were tested against 32 antimicrobial agents using the broth microdilution method. Phylogenetic analysis of the 16S rRNA gene was performed to identify the species.

Results

Three sequences from samples collected in Hainan Province did not match any known Nocardia species, suggesting significant genetic diversity among Nocardia isolates. Nocardia strains generally exhibited high resistance to

SUBMITTER: Zhao P 

PROVIDER: S-EPMC12647940 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature