Characteristics of cardiac toxicity after definitive radiation therapy for thoracic esophageal cancer in Japanese patients.

ABSTRACT: In recent years, there has been growing interest in cardiac toxicity following radiation therapy (RT) for esophageal cancer; however, detailed incidence and risk factors in Japanese patients remain unclear. The purpose of this study was to clarify the incidence, timing, risk factors, and dose-volume relationships of multiple cardiac toxicities, including pericardial effusion, heart failure, arrhythmia, cardiac valve disease and acute coronary syndrome. We retrospectively analyzed patients of thoracic esophageal cancer without distant metastasis who were treated with curative RT at our hospital between 2007 and 2020. Cardiac toxicity events were graded according to common terminology criteria for adverse events v5.0. Association between cardiac dose-volume parameters and grade 2 or higher t

SUBMITTER: Tsukahara K 

PROVIDER: S-EPMC12648062 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature