Investigation of radiation-induced DNA damage repair-related genes as diagnostic biomarkers for radiation.

ABSTRACT: Radiation exposure is a significant risk factor for various tumors and illnesses, with early-stage radiation dose closely linked to disease progression. Accurate assessment of radiation exposure is critical for effective treatment. This study aimed to identify radiation-induced DNA damage repair-related genes using weighted gene co-expression network analysis on datasets GSE90909 and GSE102971, supplemented by literature. A protein-protein interaction network was constructed to identify key genes, and their expression levels were compared between irradiated and control groups to evaluate diagnostic efficacy. Immune-related scores were calculated, and correlations between diagnostic genes and immune cells were analyzed. Regulatory networks involving transcription factors (TFs), microRNAs (m

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12648068 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature