Research on the dose calculation of BNCT based on the time-varying boron concentration in pharmacokinetics.

ABSTRACT: Boron Neutron Capture Therapy (BNCT) is a targeted radiotherapy that utilizes the nuclear reaction of 10B with thermal neutrons to destroy tumor cells while sparing healthy tissue. Its effectiveness relies on accurately modeling boron distribution. Current treatment planning systems use a fixed tumor-to-normal tissue (T/N) boron ratio, ignoring pharmacokinetics. This study improves BNCT dose calculations by integrating time-dependent boron concentrations from pharmacokinetic simulations. Firstly, this research improved the traditional two-compartment pharmacokinetic model to a three-compartment model to better represent boron distribution, accounting for different tumor locations. Two patient cases were simulated, and the comparisons were performed between the dose distributions obtained b

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12648076 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature