Regulatory relationships among <i>aldB</i>, <i>ampH</i>, and <i>acoR</i> and their impact on β-lactam susceptibility in <i>Phytobacter diazotrophicus</i>.

ABSTRACT:

Background

Phytobacter diazotrophicus (P. diazotrophicus) is an emerging opportunistic pathogen responsible for various human infections. However, it remains unclear whether aldehyde dehydrogenase B (aldB) mediates antibiotic resistance in P. diazotrophicus, and whether acetoin catabolism operon regulator (acoR) gene is associated with antibiotics. This study aims to explore the association between the aldB gene and bacterial susceptibility to β-lactam antibiotics, investigate the potential mechanism by which aldB mediates antibiotic resistance, and clarify the regulatory mechanism of aldB by the upstream adjacent gene acoR.

Methods

Gene knockout was performed using homologous recombination. The minimum inhibitor

SUBMITTER: Lin J 

PROVIDER: S-EPMC12648084 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature