Magrolimab (Hu5F9-G4) promotes macrophage M1 polarization and is associated with enhanced autophagy in colorectal cancer.

ABSTRACT:

Background

The role of macrophage infiltration in colorectal cancer (CRC) and its implications for prognosis remains uncertain. While macrophage immune checkpoint inhibitors have shown efficacy in treating solid tumors, their impact on CRC progression and immune regulation is unclear.

Purpose

This study investigates the effect of the macrophage immune checkpoint inhibitor Hu5F9-G4 on the immune microenvironment, macrophage behaviour, and CRC progression to identify potential therapeutic targets.

Methods

A total of 73 CRC samples were analysed to evaluate the association between M2d macrophage infiltration and prognosis. In vitro studies examined the effect of Hu5F9-G4 on M2d-to-M1 polarization, CRC cell proliferation, and migration. In vivo experiments assessed tumor

SUBMITTER: Lin WR 

PROVIDER: S-EPMC12648091 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature