Concanamycins Are Key Contributors to the Virulence of the Potato Common Scab Pathogen Streptomyces scabiei.

ABSTRACT: The soil-dwelling bacterium Streptomyces scabiei is distributed worldwide and is the best-characterised causative agent of common scab disease, which impacts potato crops and causes significant economic losses to growers. The principal pathogenicity factor responsible for common scab development is the phytotoxin thaxtomin A, which functions as a cellulose biosynthesis inhibitor in plants. S. scabiei also produces polyketide compounds belonging to the concanamycin family, which serve as inhibitors of eukaryotic vacuolar-type ATPases and have been shown to exhibit phytotoxic activity against different plant species. It has been proposed that concanamycins contribute to the virulence of S. scabiei, but direct evidence of this has been lacking. Using constructed strains of S. scabiei that are

SUBMITTER: Vincent CV 

PROVIDER: S-EPMC12648119 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature