Variable GLP-1 receptor expression across diverse neuroendocrine neoplasms: implications for incretin therapies.

ABSTRACT: Neuroendocrine neoplasms (NENs) are rare cancers originating in various organs and are further classified as well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Commonly used drugs such as proton pump inhibitors can promote gastric NEN growth. Nowadays, incretin mimetic drugs such as glucagon-like peptide 1 receptor (GLP-1R) agonists have gained extensive popularity for the treatment of diabetes and obesity. These drugs target GLP-1R, and their use in neuroendocrine cancer patients with medullary thyroid carcinoma (thyroid NET) or multiple endocrine neoplasia syndrome type 2 is deemed contraindicated. Previous studies investigated GLP-1R expression in small subsets of NENs. Here, we assessed GLP-1R expression by immunohistochemistry

SUBMITTER: Ear PH 

PROVIDER: S-EPMC12648204 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature