Mendelian Randomization Mediation Analysis Reveals the Impact of Dietary Preferences on Preeclampsia and Fetal Growth Restriction via Immune Modulation.

ABSTRACT: Preeclampsia (PE) and fetal growth restriction (FGR) are major causes of maternal and neonatal complications. Emerging evidence suggests that dietary preferences may influence their development, but the mechanisms, especially involving immune cells, are not well understood. We performed a two-sample Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data for dietary preferences, PE, and FGR, sourced from the GWAS Catalog (n = 159,579) and FinnGen (n = 242,332 for PE; n = 254,618 for FGR). Genetic instruments for 731 immune cell traits were extracted from the IEU GWAS database. The primary analysis employed the inverse-variance weighted (IVW) method, with sensitivity analyses (Cochran's Q test, MR-Egger intercept, and MR-PRESSO) to a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12648301 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature