A Novel Mitochondria-Associated Programmed Cell Death-Related Prognostic Model and Validation of Oncogene INHBB in Colorectal Cancer.

ABSTRACT:

Objective

The objective of this study is to explore mitochondria-associated programmed cell death (mtPCD)-related key biomarkers for patients with colorectal cancer (CRC).

Methods

CRC-related datasets were obtained from the GEO and TCGA databases, and mitochondria-related genes (MitoRGs) and PCD-related genes (PCDRGs) were acquired from the MitoCarta database or pertinent literature. After differentially expressed gene (DEG) screening, the DEmtPCD coexpressed genes were identified. Then, consensus clustering analysis was conducted, followed by GSEA and immune infiltration analysis. In addition, a prognostic model was constructed, and then, immune infiltration analysis, GSEA, and drug sensitivity analysis were carried out. The qRT-PCR and western blot were employed to determi

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12648302 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature