A Water-Based and Continuous-Flow-Usable Cascade: Sustainable Synthesis of Tetrazolo-Fused Heterocycles.

ABSTRACT: The innovation of energetic materials is frequently hampered by economic inefficiency and safety concerns. Emerging cascade reactions could overcome existing bottlenecks and accelerate next-generation energetic materials with enhanced scalability and reduced risks. In this work, a water-based cascade reaction has been applied to obtain 6-amino-7,8-dihydrotetrazolo-[5,1-f]-[1,2,4]-triazin-8-ol (AHTO), a new nitrogen-rich energetic compound. Using water as a green, multifunctional medium, this strategy achieves three critical advances: (1) elimination of intermediate isolation through cascade reaction integration, (2) minimization of toxic solvents and hazardous reagents, and (3) stabilization of sensitive tetrazolo intermediates. The inherent safety benefits of water-mediated

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12648318 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature