Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea.

ABSTRACT:

Aims

Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.

Methods

For 121 PNG HIV/AIDS patients receiving combination antiretroviral therapy (300 mg lamivudine, 300 mg tenofovir disoproxil fumarate, 600 mg efavirenz, single tablet once daily), age, body weight, sex and serum creatinine concentrations data were recorded. Plasma lamivudine and tenofovir concentrations were simultaneously quantified by liquid chromatography-tandem mass spectrometry. Univariate and multivariate linear regression analyses were performed to assess the association of demographic covariates and kidn

SUBMITTER: Andriguetti NB 

PROVIDER: S-EPMC12648361 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature