Model-based evaluation of the interaction between ritonavir-boosted atazanavir and rifampicin in Ugandan adults with HIV.

ABSTRACT:

Aim

Concomitant treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug-drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir-boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC).

Methods

The DERIVE study (NCT04121195) recruited Ugandan adults with HIV (not TB) on ATV/r-based second-line antiretroviral therapy, and collected intensive plasma and PBMC pharmacokinetic samples during four visits: (i) standard-dose ATV/r 300/100 mg QD, (ii) same ATV/r regimen adding rifampicin 600 mg QD, (iii) doubling ATV/r to BID with rifampicin 600 mg QD and (iv) ATV/r 300/100 mg BID with rifampicin increased to 1200 mg QD. ATV/r plasma and PBMC concentrations were analysed with

SUBMITTER: Kengo A 

PROVIDER: S-EPMC12648368 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature