Single-Cell Atlas of Aging Human Skin Reveals FOSB-Related Transcriptional Programs and Druggable Targets.

ABSTRACT:

Background

While human skin aging involves complex transcriptional alterations, the cell-type-specific regulatory mechanisms and therapeutic targets remain incompletely defined. The study aims to investigate aging-associated transcriptional programs and drug-responsive signatures at single-cell resolution.

Method

Here we performed a single-cell RNA sequencing of young and elder human skin cells and provided a comprehensive analysis of aging-related genes, a gene regulatory network with immunohistochemistry (IHC) validation, cell-cell interference as well as potential chemical reactions.

Result

Total 10 distinct cell populations were analyzed based on the scRNA sequencing data. Gene regulatory network analysis showed decreased lactotransferrin gene expression and incre

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12648372 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature