The impact of hypoxia on the cellular phenotype and proteome of KGN cells.

ABSTRACT:

Graphical abstract

Abstract

Human KGN cells are a widely studied cellular model for human granulosa cell tumors (GCTs), as well as for non-tumorous human granulosa cells. Such studies are typically performed at oxygen (O2) levels that are equivalent to the atmospheric concentration for practical reasons. However, in most tissues of the human body, as well as in tumors, much lower O2 levels exist. Hypoxic conditions can regulate the phenotype and the behavior of cells in a cell-type-specific way. However, how they may impact KGN cells was not well known. The aim of this study was therefore to evaluate the consequences of a defined hypoxic condition (1% O2; 10 days) in KGN cells. Compared to cells cultured in atmospheric conditions, hypoxia reduced the numbers and increased t

SUBMITTER: Hofner M 

PROVIDER: S-EPMC12648380 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature