Hierarchically porous copper and gallium loaded sol-gel phosphate glasses for enhancement of wound closure.

ABSTRACT: In this work, we have developed hierarchically porous phosphate-based glasses (PPGs) as novel materials capable of promoting wound closure and simultaneously delivering antibacterial effects at the glass-biological tissue interface. PPGs are characterised by extended porosity, which enhances the controlled release of therapeutic ions, whilst facilitating cell infiltration and tissue growth. Two series of PPGs in the systems P₂O₅-CaO-Na₂O-CuO and P₂O₅-CaO-Na₂O-Ga₂O₃ with (CuO and Ga₂O₃ 0, 1, 5 and 10 mol%) were manufactured using a supramolecular sol-gel synthesis strategy. Significant wound healing promotion (up to 97%) was demonstrated using a human ex vivo wound model. A s

SUBMITTER: Berry CA 

PROVIDER: S-EPMC12648381 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature