Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus.

ABSTRACT:

Background

Many environmental chemicals have been shown to cross the placental barrier, threatening the health of offspring. Additionally gestational diabetes mellitus (GDM) may affect the transplacental transfer ratios (TTRs) of environmental chemicals, but the rate of transfer of a wide variety of environmental chemicals have not been widely studied.

Objective

We examined the TTRs of per- and poly- fluoroalkyl substances (PFAS), phthalates, parabens, bisphenols, and benzophenones in pregnant women, and if GDM increases transplacental transfer of these chemicals.

Methods

We examined 576 mother-newborn pairs from the Growing up in Singapore Towards healthy Outcomes (GUSTO) birth cohort enrolled 2009-2010. Fetal cord plasma to maternal plasma ratios from samples around

SUBMITTER: Leader J 

PROVIDER: S-EPMC12648410 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature