Phenothiazine-Based Fluorescence-Quenched Photoacoustic Contrast Agents for Molecular Imaging.

ABSTRACT: Photoacoustic imaging (PAI), renowned for its high spatial resolution and deep tissue penetration, holds great promise for disease diagnosis and molecular detection. However, the performance of commercially available PAI contrast agent is often hindered by intrinsic fluorescence, which reduces photoacoustic (PA) signal intensity and contrast, thereby limiting their applications. Herein, we rationally designed and synthesized a class of PAI contrast agents based on a phenothiazine core. By precise molecular engineering, we introduced a twisted intramolecular charge transfer (TICT) effect to suppress fluorescence, minimize radiative decay, and facilitate nonradiative energy dissipation, thereby enhancing photothermal conversion efficiency and significantly improving PA signal intensity and i

SUBMITTER: Huang X 

PROVIDER: S-EPMC12648425 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature