PH-Responsive Liposomes for Targeted Detection of Pancreatic Adenocarcinoma Using MSOT.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) diagnosis and treatment are limited due to the insufficient availability of contrast agents that can detect tumors with high sensitivity and specificity. Nanocontrast agents can be actively targeted toward the highly acidic tumor microenvironment to facilitate the detection of tumor cells during intraoperative imaging using an advanced imaging modality: multispectral optoacoustic tomography (MSOT). We developed IR780 dye encapsulated liposomes (Lipo-780) as a nanocontrast agent and actively targeted them using the pH low insertion peptide (pHLIP) V7 (V7-lipo-780) toward the extremely acidic pH tumor microenvironment of pancreatic cancer. Tumor-specific uptake of liposomes were evaluated in vitro in aggressive metastatic pancreatic cancer cells

SUBMITTER: Agarwal H 

PROVIDER: S-EPMC12648426 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature