Histologic Response to Induction Chemotherapy in High-Risk Neuroblastoma.

ABSTRACT:

Introduction

Tumor histology at diagnosis is used in conjunction with other prognostic features to risk stratify patients with neuroblastoma and to assign therapy regimens. In patients with high-risk disease, adjustment of therapy is tailored to treatment response, largely based on disease imaging following induction chemotherapy and resection of the primary tumor. The goals of this study were to (i) quantify changes in histologic features in the primary tumor between diagnosis and resection, and (ii) assess the prognostic capability of such alterations.

Methods

Tumor histology from paired samples at diagnosis and resection was evaluated from 94 patients with high-risk neuroblastoma enrolled in Children's Oncology Group (COG) trials from 2001 to 2013. Presence of Schwannian

SUBMITTER: Pomaville M 

PROVIDER: S-EPMC12648435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature