Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts.

ABSTRACT:

Background

Nuclear magnetic resonance (NMR) spectroscopy enables the characterisation of lipoprotein sub-particles, providing a more detailed lipid profile than the conventional lipid measurements, with potential clinical relevance, particularly in cardiovascular disease (CVD), which remains the leading cause of mortality worldwide. Nonetheless, for clinical implementation, it is essential to first determine the normal variation of lipoprotein parameters by age and sex.

Methods

This cross-sectional study analysed a large dataset of 31,275 serum or plasma samples from five different countries using the B.I.LISA™ NMR-based platform, quantifying 112 lipoprotein parameters, including subclass size and concentration. Lipoprotein parameters from specific cohorts were fitted to a Q

SUBMITTER: Conde R 

PROVIDER: S-EPMC12648477 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature