Identification of specific brain cell types associated with the interplay between inflammatory bowel diseases and neuropsychiatric disorders by Cell-Stratified Mendelian Randomisation.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) has been suggested to be associated with neuropsychiatric disorders, but the underlying mechanisms remain poorly understood.

Methods

We employed Cell-Stratified Mendelian Randomisation (csMR) to analyse genetic variants associated with IBD and their effects on neuropsychiatric disorders. We conducted two-sample MR analyses using the partitioned genetic variants and performed SuSiE co-localisation analysis to identify shared causal variants between GWAS traits and the single-cell eQTL data. We also examined the imaging-derived phenotypes (IDPs) to understand the structural changes in the brain.

Findings

We identified specific cell types and IDPs associated with the interplay between IBD and neuropsychiatric disorders. Importa

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12648484 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature