Tibial to ulnar nerve amplitude ratio as a marker of length-dependent neuropathy.

ABSTRACT:

Objective

To evaluate the utility of nerve conduction studies as a marker of length-dependent neuropathy.

Methods

We conducted a retrospective study of 44 chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients and 365 genetically confirmed Charcot-Marie-Tooth disease (CMT) patients, including those with PMP22 duplications or mutations in GJB1, MFN2, MPZ, and MME. Nerve conduction study parameters were compared, with subgroup analyses of CIDP-mimicking CMT (genetically confirmed CMT with a prior clinical diagnosis of CIDP) and gene-based classifications. Receiver operating characteristic (ROC) analysis assessed the sensitivity and specificity of these parameters.

Results

The tibial to ulnar nerve distal compound mus

SUBMITTER: Yano C 

PROVIDER: S-EPMC12648492 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature