Unravelling the causal link between gut microbiota and acne risk using a genetic approach.

ABSTRACT:

Background

Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders.

Objectives

To investigate the causal relationship between gut microbiota and acne.

Methods

This study investigated the causal relationship between gut microbiota and acne using a two-sample Mendelian randomization (MR) approach with large-scale genome-wide association study summary statistics. To ascertain the direction of causality and the independent effect of gut microbiota, reverse MR and multivariable MR accounting for dietary phenotypes were

SUBMITTER: Cao F 

PROVIDER: S-EPMC12648534 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature