Genetic syndromes in paediatric alopecia areata: a systematic review.

ABSTRACT:

Background

A wide variation of phenotypes is displayed by individuals with alopecia areata (AA), especially in the paediatric population.

Objectives

To systematically search published studies to identify paediatric syndromes with AA and their clinical features, and to summarize the current state of their genetic elucidation.

Methods

In accordance with the PRISMA guidelines, a systematic search of MEDLINE, Embase, CENTRAL and PubMed databases was performed. All original case reports, case series and observational studies describing AA in children (aged <18 years) with monogenic or chromosomal syndromes were included. Further searches in OMIM and Orphanet, and reviews, clinical guidelines and basic science studies were used to retrieve additional comprehensive informati

SUBMITTER: Park M 

PROVIDER: S-EPMC12648540 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature