PTSD and suPAR: A multicohort investigation of chronic inflammation.

ABSTRACT: Posttraumatic stress disorder (PTSD) is associated with poor health. Prior research has shown stressful events are associated with inflammatory biomarkers, such as soluble urokinase plasminogen activator receptor (suPAR), suggesting systemic chronic inflammation could be a mechanism linking adversity to poor health. In this study, we examined associations of PTSD and suPAR in two research cohorts-the E-Risk Study (United Kingdom; n = 1,389) and the Dunedin Multidisciplinary Health and Development Study (New Zealand; n = 927)-and a clinical cohort of medical patients (Denmark; n = 29,285). We also present results from two commonly assessed inflammatory biomarkers: C-reactive protein (CRP) and interleukin-6 (IL-6). People with a lifetime history of PTSD had higher suPAR at age 18 in E-Risk (

SUBMITTER: Bourassa KJ 

PROVIDER: S-EPMC12648567 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature