Chaperonins in Hepatocellular Carcinoma: Unveiling Their Role in Tumor Proliferation and Immune Modulation Through Multiomics Analysis.

ABSTRACT:

Background

Chaperonins are crucial regulators of tumor biology by controlling the stability and function of oncogenic and tumor-suppressor proteins, influencing various tumorigenic signaling pathways. Although chaperonins have been widely discussed in various cancers, including hepatocellular carcinoma (HCC), the complex mechanisms by which they contribute to HCC progression remain insufficiently explored and require further investigation.

Methods

Based on data from public databases, we screened chaperonin members from the Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) database. The screened genes were subjected to differential expression analysis, survival analysis, clinical correlation, and univariate Cox regression. Results were validated using single

SUBMITTER: Wang SH 

PROVIDER: S-EPMC12648626 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature