Mitochondrial genome analysis supports zoonotic transmission of triclabendazole-resistant human fascioliasis in Peru.

ABSTRACT: Fascioliasis is a parasitic infection caused by Fasciola spp., primarily affecting ruminant animals. These digenean flatworms cause severe liver damage in their hosts, resulting in substantial economic losses within the livestock industry. Human fascioliasis is an emerging public health concern, with an estimated global prevalence of 2.6 million cases. Infection in humans typically occurs through the ingestion of aquatic vegetation or water contaminated with metacercariae. Triclabendazole (TCBZ) remains the only drug recommended by WHO for the treatment of human fascioliasis and is widely used in livestock. However, the increasing prevalence of TCBZ resistance in livestock, along with reports of TCBZ-resistant human infections, poses a growing challenge to disease control. Although

SUBMITTER: Kumar P 

PROVIDER: S-EPMC12648724 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature