Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics.

ABSTRACT:

Background

Drug metabolism va-specific dosing. Strychnine, the primary active compound in strychnine-based alkaloids, is used for treatment of hemiplegia or amblyopia. However, knowledge of sex-based difference in the pharmacokinetics of strychnine remains limited, increasing the risk of dosage error and potential toxicity in patient.ries between men and women derived from the difference in body fat distribution and hormone secretion, necessitating sex.

Method

Rats were divided into intact (possessing reproductive organ) and gonadectomized (GDX) groups, including 6 males and 6 females in each one. In the GDX rat group, testes were removed from male rat at 5 weeks of age, while ovaries were removed from female rat. The GDX rats were maintained for an additional 15 days. All i

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12648864 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature