Association of blood-based DNA methylation of lncRNAs with Alzheimer's disease diagnosis.

ABSTRACT:

Background

DNA methylation has shown great potential in Alzheimer's disease (AD) blood diagnosis. However, the ability of long non-coding RNAs (lncRNAs), which can be modified by DNA methylation, to serve as noninvasive biomarkers for AD diagnosis remains unclear.

Methods

We performed logistic regression analysis of DNA methylation data from the blood of patients with AD compared and normal controls to identify epigenetically regulated (ER) lncRNAs. Through five machine learning algorithms, we prioritized ER lncRNAs associated with AD diagnosis. An AD blood diagnosis model was constructed based on lncRNA methylation in Australian Imaging, Biomarkers, and Lifestyle (AIBL) subject and verified in two large blood-based studies, the European collaboration for the discovery of no

SUBMITTER: Tian G 

PROVIDER: S-EPMC12648935 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature