Metabolomic and microbiome integration of Han-Tibetan and plain-plateau populations.

ABSTRACT:

Background

Recent studies focus on the genetic and physiological characteristics of the plains Han, plateau Han, and Tibetan populations. However, systematic studies on the differences in metabolic and microbial communities in high-altitude environments remain limited.

Results

This study profiled metabolomes and microbiomes in plain Han, plateau Han, and Tibetan populations. Differential analysis revealed 30 metabolites and notable alterations in microbial community composition between plain Han and plateau Han. Prevotella, Streptococcus, and Ruminococcus, mainly participating in purine metabolism, were enriched in the plateau Han population. Bacteroidota and Firmicutes were the primary differential bacterial phyla indicating adaptive alternatives, particularly in steroid me

SUBMITTER: Li P 

PROVIDER: S-EPMC12648999 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature