Prognostic Implications of Myositis-Specific Autoantibodies on Mortality, Relapse, and Remission in Dermatomyositis Patients.

ABSTRACT:

Objectives

To explore the clinicopathological features and treatment prognosis including death, relapse and remission of dermatomyositis (DM) based on myositis-specific autoantibody (MSAs) stratification.

Methods

Patients with DM come from a provincial neuromuscular center in northern China. Patients who underwent biopsy from 2010 to 2023 were collected, and the follow-up time was all more than 6 months. Clinical characteristics, serum samples, and muscle biopsies were collected. Kaplan-Meier analysis, Cox regression, and competing risk model were used for analysis.

Results

Our study included 140 patients with DM. Among the 25 juvenile patients, 9 (36%) were anti-NXP2 antibody positive. About 80.95% of the patients with anti-TIF1-γ antibodies had neck flexion weakness

SUBMITTER: Hou Y 

PROVIDER: S-EPMC12649061 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature