Neutrophil-Mimicking Prussian blue nanozymes for synergistic targeted immuno-metabolic therapy of hepatic ischemia-reperfusion injury.

ABSTRACT: Liver ischemia-reperfusion injury (IRI), an unavoidable complication during liver resection and transplantation, leads to significant postoperative liver failure and graft dysfunction. This injury is driven by severe oxidative stress, inflammation, and metabolic disruption, with clinical management hindered by the absence of effective multi-target therapies. This study introduces a novel therapeutic platform: neutrophil membrane-coated Prussian blue nanozymes (PBN) delivering metformin (Met@PBN@Neu-CVs). The neutrophil membrane coating enables active targeting of the nanoparticles to the inflamed liver site, enhancing accumulation of the PBN and metformin. Concurrently, neutrophil membrane-coated vesicles (Neu-CVs) adsorb circulating inflammatory cytokines, mitigating inflammation. Crucial

SUBMITTER: Shen P 

PROVIDER: S-EPMC12649080 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature