Characterization of intramuscular Isoflupredone acetate in horses: pharmacokinetics and effects on anti-inflammatory mediators and plasma electrolytes.

ABSTRACT:

Background

Corticosteroids, such as isoflupredone, are effective anti-inflammatory medications and as such are commonly used to treat inflammation associated with training and injuries in performance horses. While the pharmacokinetics and pharmacodynamics of isoflupredone acetate (IPA) following intra-articular administration to horses has been well described, studies characterizing intramuscular (IM) administration are lacking. The objective of the current study was to describe the pharmacokinetics and anti-inflammatory effects of IPA following IM administration to horses. Twelve horses received a single IM dose of 20 mg IPA, and blood and urine samples were collected starting at 5 min (blood) and 24 h (urine) until 312 h. Concentrations of isoflupredone were determined using liqu

SUBMITTER: Sullivan J 

PROVIDER: S-EPMC12649081 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature