Neuron-derived extracellular vesicles reflect adaptive neuronal responses to cortical spreading depolarization: a biomarker study for migraine.

ABSTRACT:

Background

Small extracellular vesicles (EVs) are nano-sized membranous particles transporting bioactive cargo, including proteins. In the central nervous system (CNS), neuron-derived EVs (nEVs) are thought to play roles in synaptic plasticity, metabolic regulation, and neuroinflammation. While their relevance in neurodegenerative and neuroinflammatory disorders is increasingly recognized, their role in migraine pathophysiology remains underexplored.

Objective

This study aimed to investigate the proteomic signature of nEVs isolated from the cortex of mice subjected to cortical spreading depolarization (CSD), a neurobiological event underlying migraine aura. We sought to identify molecular pathways activated in neurons during CSD and evaluate the potential of nEVs as biomarke

SUBMITTER: Sever-Bahcekapili M 

PROVIDER: S-EPMC12649082 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature