Exploring the Anticancer Potential of the Multistrain Probiotic Formulation <i>OxxySlab</i> in Bladder Cancer Cell Lines.

ABSTRACT: Bladder cancer (BC), particularly its muscle-invasive subtype (MIBC), remains a clinical challenge due to high recurrence and limited therapeutic options. Emerging evidence suggests that probiotics may offer selective anticancer effects while preserving healthy tissue. In this study, we evaluated the antitumor potential of OxxySlab, a multistrain probiotic formulation, in two BC cell lines (T24 and 5637) and a non-tumorigenic urothelial cell line (SV-HUC1). OxxySlab lysate dose-dependently inhibited BC cell proliferation, clonogenicity, and migration, while sparing normal cells. Mechanistically, the treatment suppressed epithelial-mesenchymal transition (EMT), induced senescence, and disrupted redox homeostasis in malignant cells. These effects were associated with the induct

SUBMITTER: Ciummo V 

PROVIDER: S-EPMC12649232 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature