Role of Matricellular Proteins in Endothelial Cell Inflammation and Atherosclerosis.

ABSTRACT: The vascular endothelium serves as a critical barrier preventing the transmigration of monocytes, circulating lipoproteins, and other molecules into the subendothelial space, and plays a vital role in regulating vascular tone. A dysfunctional and inflamed endothelial layer in response to disturbed blood flow or other proatherogenic risk factors is the initiating event in the pathogenesis of atherosclerosis, suggesting the importance of an intact and properly functioning endothelium in preventing the onset and progression of this disease. Accumulated evidence demonstrates the significant role of matricellular proteins, which are non-structural and secretory extracellular matrix (ECM) proteins, in the development of atherosclerosis. These proteins exert multifaceted effects on endothelial ce

SUBMITTER: Aithabathula RV 

PROVIDER: S-EPMC12649302 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature