Evolutionary Dynamics of Matrix Metalloproteases with Collagenolytic Activity in Teleosts.

ABSTRACT: Matrix metalloproteases (MMPs) are zinc-dependent endopeptidases that are critical for extracellular matrix (ECM) remodeling, with key roles in tissue development and repair, and immune responses. Despite their evolutionary and functional importance, the diversification and regulatory dynamics of MMPs genes in teleosts remain poorly understood. This study investigates the evolutionary history of MMPs with collagenolytic activity in the vertebrates with an emphasis on teleosts. Using comparative genomics and phylogenetics we identified conserved single-copy mmp2 and mmp9 genes and duplicated mmp11 and mmp13 paralogs in all non-salmonid teleosts. Phylogenetic and synteny analyses suggest that mmp11 paralogs originated from the teleost-specific genome duplic

SUBMITTER: Angelakopoulos R 

PROVIDER: S-EPMC12649390 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature