Optimized 3D-Printed Polylactic Acid/Graphene Oxide Scaffolds for Enhanced Bone Regeneration.

ABSTRACT:

Background

Three-dimensional (3D) printed scaffolds have emerged as promising tools for bone regeneration, but the optimal structural design and pore size remain unclear. Polylactic acid (PLA) reinforced with graphene oxide (GO) offers enhanced mechanical and biological performance, yet systematic evaluation of architecture and pore size is limited.

Methods

Two scaffold architectures (lattice-type and dode-type) with multiple pore sizes were fabricated using UV-curable PLA/GO resin. Physical accuracy, porosity, and mechanical properties were assessed through compression and fatigue testing. Based on in vitro screening, four pore sizes (930 μm, 690 μm, 558 μm, 562 μm) within the dode-type structure were analyzed. The 558 μm and 562 μm scaffolds, showing distinct fracture thre

SUBMITTER: Lee JT 

PROVIDER: S-EPMC12649579 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature