Transcriptome Analysis Reveals Circadian Rhythmic Regulation of Lipid Metabolism and Immune Function in Chicken Livers.

ABSTRACT: Liver rhythm has a significant effect on lipid metabolism and immune function in chickens. However, reports on its underlying mechanisms and key genes are relatively scarce. We collected liver samples at seven time points during one light/dark cycle and investigated the candidate genes and pathways related to hepatic rhythm through transcriptomic sequencing. Trend analysis revealed that the expression of genes in Profile 5 exhibited rhythmic fluctuations, and these genes (e.g., FAM21C, SRSF4, and TLR2A) were enriched in immune function and biological rhythm. The genes (e.g., MSMO1, ELOVL2, and HMGCR) in Profile 2 that were related to lipid metabolism also exhibited a rhythmic trend. A total of 845 differentially expressed genes (e.g., MSMO1

SUBMITTER: Li J 

PROVIDER: S-EPMC12649623 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature