Tuning the Structure-Functional Properties Within Peptide-Mimicking Antimicrobial Hydrogels.

ABSTRACT: Background/Objectives: There is a growing demand for the development of novel antimicrobial agents due to their efficacy being eroded by increasing antimicrobial resistance. Antimicrobial hydrogels have been reported as a method to treat bacterial infections. Methods: This study explores how different structural features are important for the hydrogelation properties of amphiphilic antimicrobial peptide-mimics through rheology and AFM, as well as properties important for antimicrobial activity measured through MIC. Results: Eleven novel peptide-mimicking anthranilamides containing various structural features were synthesised in 4-7 steps. Of these peptide-mimics, three novel compounds formed hydrogels, and it was identified that their mechanical strength, secondary str

SUBMITTER: Attard ST 

PROVIDER: S-EPMC12649725 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature