Mediating role of proteomics in the association between per- and polyfluoroalkyl substance exposure and blood pressure in youth.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants linked to elevated blood pressure (BP). However, research has largely focused on adults and underlying mechanisms are not fully understood. We evaluated associations between PFAS and BP in youth and examine potential mechanisms by leveraging proteomics. We analyzed data from two cohorts at baseline and follow-up: 312 adolescents from Study of Latino Adolescents at Risk (SOLAR) (2001-2012) and 137 young adults from Children Health Study (CHS) (2014-2018). Baseline plasma PFAS were measured using liquid chromatography-mass spectrometry, with PFAS burden scores calculated. Baseline plasma proteins were measured using Olink's Cardiometabolic Panel I. Systolic and diastolic BP (SBP, DBP) were measured at baseline and f

SUBMITTER: Chen JC 

PROVIDER: S-EPMC12649767 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature