New-onset prediabetes/diabetes worsens overall survival in patients with cancer: A real-world retrospective cohort study.

ABSTRACT:

Aims

Cancer diagnosis may increase the risk of developing prediabetes/diabetes and subsequently worsen survival in cancer patients. However, it is unclear whether this association is influenced by the timing of hyperglycemia onset or the use of antihyperglycemic medications.

Materials and methods

This study leveraged a retrospective cohort, constructed using electronic health record data, of solid tumour patients at the Huntsman Cancer Institute, a comprehensive cancer centre in Utah, USA. Adjusted Cox proportional-hazards regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) to evaluate the association between new-onset prediabetes/diabetes and overall survival.

Results

Of the 7300 patients included, 23% developed prediabetes/d

SUBMITTER: Winn M 

PROVIDER: S-EPMC12649824 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature